WebAug 13, 2002 · N-tert-Butanesulfinyl aldimines 3 and ketimines 4 are exceedingly versatile intermediates for the asymmetric synthesis of amines. The N-tert-butanesulfinyl imines are prepared in high yields by condensing enantiomerically pure tert-butanesulfinamide 1, which is readily available in either configuration, with a wide range of aldehydes and ketones. … WebSep 2, 2024 · Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary Authors: Bofei Wang Fangrui Zhong Abstract and Figures Herein, we described a new protocol for...
Applications of tert-butanesulfinamide in the synthesis of N ...
WebNov 29, 2011 · A process has been designed and demonstrated for the asymmetric synthesis of sulfinamides using quinine as auxiliary. A variety of chiral sulfinamides … Web6. Ellman reported the production of tert-butanesulfinic acid on treatment of a sulfinamide with TFA-d 1/D 2O in an NMR study but it was not isolated: (a) Brinner, K. M.; Ellman, J. A. Org. Biomol. Chem. 2005, 3, 2109–2113; Ellman used NH 4Cl as an additive for auxiliary cleavage by acidic resins and MeOH, and tarte apple treat crossword clue
Synthesis and applications of tert-butanesulfinamide.
WebJan 26, 2024 · Additions of non-stabilized carbon nucleophiles to chiral N-sulfinyl imines involve the reaction of an organometallic reagent with a chiral N -sulfinyl imine to afford chiral amines in a highly stereoselective … Websulfinamide using Ti(OEt) 4followed by addition of NaBH 4to the reaction solution at –48 °C. The sul-finamide products are obtained in 66–86% yields for the process and with … WebJun 11, 2024 · One of the most interesting transformations that can be performed with a chiral sulfinamide is its condensation onto a ketone to form a chiral sulfinylketimine, followed by a reduction to obtain an α-chiral primary amine. We review here all the methodologies developed around this condensation/reduction transformation. In the … tarte aquacenter concealer swatch