WebThe cytoplasmic linker protein-170 (CLIP-170) was the first TIP identified (9, 10). Subsequently, numerous structurally unrelated TIP proteins have been iden-tified that are evolutionarily conserved in most eukaryotes. Genetic and biochemical studies have revealed that … WebFeb 18, 2002 · We have identified a new member of the CLIP-170 family that behaves as a cytoplasmic linker protein involved in the TGN–endosome dynamics. The structure of …
cytoplasmic linker protein CLIP-170 is a human autoantigen
WebJan 18, 2024 · Cytoplasmic linker protein 170 (CLIP-170) is a microtubule plus-end factor that links vesicles to microtubules and recruits the dynein-dynactin complex to … WebJun 21, 2024 · Rapamycin-driven enhancement of the AP-2–dynactin interaction also required the presence of cytoplasmic linker protein 170 (CLIP-170) and activation of autophagy. The latter was sufficient to enhance the AP-2β interaction with p150 Glued, even when mTORC1 was active. Altogether, our results show that autophagy regulates the AP … shvatio
Structural basis for tubulin recognition by cytoplasmic …
WebCytoplasmic linker protein 170 (CLIP-170), the prototype +TIP, was proposed to bind to MT ends with high affinity, possibly by copolymerization with tubulin, and to dissociate seconds later. However, using fluorescence-based approaches, we show that two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. ... WebApr 1, 2014 · Cytoplasmic linker protein 170 (CLIP-170), a member of microtubule plus-end tracking protein family known as +TIPs [17], [18], is associated with cell polarity and motility by forming a cortical capture complex that bridges actin filaments with microtubules [19]. The involvement of CLIP-170 in neovascularization and the underlying mechanisms … WebFeb 2, 1998 · Sequence analysis reveals that this protein is the Drosophila homologue of cytoplasmic linker protein (CLIP) 1 –170. CLIP-170 is believed to function as a linker between endocytic vesicles and microtubules ( Pierre et al., 1992 ). We have named this associated protein D-CLIP-190. the partnership model of working with parents