WebNational Center for Biotechnology Information WebNov 1, 2024 · Aryl Hydrocarbon Receptor (AHR) is a ligand-activated transcription factor as one of the sensors that facilitate cells to adapt to the environment and microorganisms in the host ( Schulte et al., 2024 ).
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WebSep 1, 2024 · AHR is a ligand-activated transcription factor that is normally located in the cytoplasm. It has been shown to be protective against hyperglycemia-induced BBB dysfunction and brain injury after... WebIn one of the projects, we have uncovered a novel pathway that mediates microglia and astrocytes crosstalk promoting their pathogenic activities during EAE, Eph receptor / signaling (Figure 1A). ... (AhR), a tolerogenic transcription factor that is normally activated by small molecules provided by the diet and the gut flora. Indeed, using ... heat exchanger performance evaluation
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WebNov 1, 2024 · However, p-AHR-positive TH-expressing cells were reduced in the SNpc, indicating that AHR may protect TH + neurons after MPTP treatment. Considering that AHR activation in microglia bidirectionally mediates pro-inflammatory and anti-inflammatory effects, we detected the activation of AHR in microglia and astrocytes in the striatum or … WebOct 6, 2024 · Microglia can send signals to astrocytes to mediate the response to the inflammatory in CNS. The microbial metabolites of tryptophan regulate the microglial activation, produce TGFα and VEGF-B, regulate CNS-related diseases, and the transcription in astrocytes through AhR. WebMar 1, 2024 · In parallel, AHR signaling in microglia limited inflammation in astrocytes by increased production of anti-inflammatory TGF-α and decreased production of proinflammatory VEGF-β [109]. Thus, shared expression of immune-modulating receptors may be another mechanism by which astrocyte and microglial inflammatory functions are … move payid to another bank